Heck, it's been called "Science fiction's Ulysses," which is good enough for me. :-)
In my travels, I often try to read books that are related to my destination. I loved Nadja in Paris, and The Name of the Rose in northern Italy. But it doesn't always work out... The Fountainhead was my companion in Kyoto, and the cognitive dissonance wasn't too crazy. We'll see the result of having Gene Wolfe at my side in Melbourne!